Potentiation of GABAA Receptors by Perfume and Phytoncid Expressed inXenopusOocytes
نویسنده
چکیده
To study the effects of perfume and phytonc;d on GABAA receptors, ionotropic GABAA receptors were expressed in Xlanopus eocytes by iajecting mRNAs that had been prepared from rat whole brain. Essential eil, pevfume and such phytoncid as leaf alcehol, hinokitiel, pinene, eugenol, citronellol and citronellal potentiated the response in the presence of GABA at low cencentratiens (10 and 30 "M), possibly because they beund to the potentiatioll-site {n GABAA receptors and increased the aMnity of GABA to the receptors. Since it is known that the potentiation ef GABAA receptors by benzodiazepine, barbiturate, steroids
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Fragrances in oolong tea that enhance the response of GABAA receptors.
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